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Obesity increases breast cancer (BC) risk in post-menopausal women by mostly unknown molecular mechanisms.
In this study, miRNA profiling by RNA-seq was performed in paired benign and malignant biopsies from 12 women at the extremes of the BMI distribution among 83 BC patients. Candidates were validated in all samples by qRT-PCR. Associations between miR-10b expression and validated target transcript levels, and effects of targeted manipulation of miR-10b levels in a primary BC cell line on proliferation and invasion potential, were explored.Read More
In this study, miRNA profiling by RNA-seq was performed in paired benign and malignant biopsies from 12 women at the extremes of the BMI distribution among 83 BC patients. Candidates were validated in all samples by qRT-PCR. Associations between miR-10b expression and validated target transcript levels, and effects of targeted manipulation of miR-10b levels in a primary BC cell line on proliferation and invasion potential, were explored.Read More
